Fibrinogen - Derived Peptide B i 91 - 42 Is

The formation and degradation of fibrin play a central role in hemostasis, but other activities have been associated with fibrin(ogen)-derived peptides, which suggests that products of fibrin(ogen) turnover may be involved in infiammation and wound healing. The present study was undertaken to determine whether the plasmic fibrinogen-derived peptide B191 -42 has effects on inflammatory cells and fibroblasts (FB). B/91 -42 was found to be a potent chemotaxin for neutrophils (PMN) and FB. maximally stimulating PMN migration at iO mol/L peptide. Unlike the chemotactic factors f-Met-Leu-Phe and C5a. B$1 -42 did not induce the release of lysosomal hydrolases and superoxide anion from PMN, nor did it stimulate directed movement of monocytes (MN). These features of B$1 -42 resemble the properties of human fibrinopeptide B (hFpB). the 14residue, thrombin-cleaveable fragment that constitutes the amino terminus of Bfl1 -42. and suggested that the chemotactic effects of B$1 -42 are mediated through its